Extended Data Fig. 10: Integrative Genetic Analysis of ANGPTL3: Mendelian Randomization and Colocalization Across Cardio-Kidney-Metabolic Traits.
From: The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health
(a) Colocalization analysis of ANGPTL3 across various cardio-kidney-metabolic GWAS traits. The x-axis represents the colocalization posterior probability, while the y-axis lists the examined traits. Kidney eQTLs, kidney pQTLs, and plasma pQTLs from various studies are represented by different shapes and colors, as indicated in the legend. Dots are colored according to their posterior probability, with grey dots representing loci where posterior probability<0.5. (b) Mendelian Randomization effect sizes and significance for ANGPTL3 across various cardio-kidney-metabolic GWAS traits. The x-axis shows the MR effect size, computed using the Wald ratio method, while the y-axis lists the examined traits. The figure includes eQTLs, kidney pQTLs, and plasma pQTLs from various studies, represented by different shapes and colors as indicated in the legend. The size of the dots corresponds to the -log10(P-value) of the MR effect size. MR P < 2.5×10^-6 was considered statistically significant. Associations not reaching this threshold are represented in grey. ASCVD, atherosclerotic cardiovascular disease; MASH, metabolic dysfunction-associated steatohepatitis; MRI_lvesvi, cardiac magnetic resonance imaging of left ventricular end-systolic volume index; MRI_lvef, cardiac magnetic resonance imaging of left ventricular ejection fraction; DCM, dilated cardiomyopathy; CAD, coronary artery disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; T2D, type 2 diabetes; 2hGlu, 2-hour glucose; GGT, gamma-glutamyl transferase; AST, aspartate aminotransferase; ALT, alanine transaminase; ALP, alkaline phosphatase; whradjbmi, waist-to-hip ratio adjusted for body mass index; TG, triglycerides; ffmi, fat-free mass index; BMI, body mass index; bfpct, body fat percentage; AOR, Aorta; SUF, subcutaneous fat; SKM, skeletal muscle; LIV, Liver.
