Extended Data Fig. 5: Depth and duration of response by PD-L1 expression.

a, b, c, waterfall plot depicting the maximum change from baseline in target lesion size in patients with PD-L1 TPS of < 1% (a), between 1 and 49% (b) and ≥ 50% (c); d, e, f, spider plots showing the percentage change from baseline in the sum of the longest diameters (SLD) of target lesions over time in patients with PD-L1 TPS of < 1% (d), between 1 and 49% (e), and ≥ 50% (f). Each line represents an individual patient; timepoints (x-axis) show scheduled assessments; the y-axis indicates SLD change (%). The end of each line is marked with a square to indicate treatment discontinuation (last assessment before stopping treatment for any reason) or a triangle to indicate treatment ongoing (patient still receiving therapy at the data cutoff). PD-L1, programmed death ligand 1; TPS, tumor proportion score.