Fig. 2: Acute AEs related to ICB by study arm and grade. | Nature Medicine

Fig. 2: Acute AEs related to ICB by study arm and grade.

From: Perioperative nivolumab or nivolumab plus ipilimumab in resectable diffuse pleural mesothelioma: a phase 2 trial and ctDNA analyses

Fig. 2

Any-grade AEs related to nivo or ipi occurring within 100 days of study drug administration or 30 days post-surgery (whichever was longer) were recorded. Any-grade AEs related to ICB occurred in 62.5% of patients in Arm A, of which 18.8% were grade 3 or higher. Grade 3 or higher ICB-related AEs in Arm A included one event each of hypokalemia, pneumonitis and upper respiratory infection. In Arm B, any-grade AEs related to ICB occurred in 57.1% of patients, of which 7.1% were grade 3 or higher. Grade 3 or higher ICB-related AEs in Arm B included one event each of alkaline phosphatase elevation and aspartate aminotransferase elevation. The breakdown of these AEs by arm is shown in light shading (any-grade AEs), whereas grade 3 or higher AEs are shown in dark shading.

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