Extended Data Fig. 7: Bioinformatics analysis for identifying minimal number of coronaviruses-targeting crRNAs.
From: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
a, Schematic describing a computational pipeline for identifying the minimal number of crRNAs targeting all coronaviruses by analyzing available coronavirus genomes. b,c, Histograms showing the predicted minimal number of 22-nt and 30-nt crRNAs with zero mismatch to target all sequenced 3,137 coronavirus genomes. d, Seventeen 30-nt crRNAs with single-nt mismatch in the minimal pool that targets all coronaviruses and their similarity with human transcriptome.
