Extended Data Fig. 10: Analysis of Human Lung Preview Dataset.
From: FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics
(a) Pixel-level visualization of inferred factor by FICTURE on a healthy human lung tissue assayed by 10x Xenium platform. An upper-left subsection was magnified in the inset. (b) Further magnified view of FICTURE’s pixel-level inference on a peribronchial region showing a signature of immune infiltration (orange in the lower center). (c) Corresponding view in the 10x Xenium Explorer based on staining-based cell segmentation, each segmented cell colored by its assigned cluster. (d) DAPI image of the same region. (e) Gene-level visualization of the same region, focusing on CD8A, CD27, IL7R, and CD28 in different colors. (f) Gene level visualization of GZMK. The full color codes and marker genes of each factor are shown in Supplementary Table 1.
