Fig. 2: Spatial mechano-transcriptomic profiling of different E8.5 mouse embryo brain regions.
From: A computational pipeline for spatial mechano-transcriptomics
a, Instance segmentation masks of cell contours (Methods) for datasets 1 (left), 2 (middle) and 3 (right). b, Spatial tension (T) maps obtained with the VMSI algorithm from the cell segmentation masks of datasets 1 (left), 2 (middle) and 3 (right). c, Spatial pressure (P) maps obtained with the VMSI algorithm from the cell segmentation masks of datasets 1 (left), 2 (middle) and 3 (right). d, Spatial maps and Uniform Manifold Approximation and Projection (UMAP) clustering plots of the cell types present in the datasets 1 (left), 2 (middle) and 3 (right). Clusters and cell types were obtained by gene expression analysis on the basis of the seqFISH and inputed gene expression profiles for all cells contained in each dataset.
