Extended Data Fig. 2: SWING’s performance on disease HLA alleles. | Nature Methods

Extended Data Fig. 2: SWING’s performance on disease HLA alleles.

From: Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions

Extended Data Fig. 2

a. Comparison of model performance on IEDB peptides for 3 human Class II disease-associated alleles (DRB1_0405, DRB1_1201, DRB1_1454) as defined by the AUROC for peptide sizes 12-21. orange, SWING Class II; magenta, SWING Mixed; green, MixMHC2pred 2.0; gray, NetMHCIIpan 4.2. b. Distribution of binding peptide sizes in the IDEB test set. MixMHC2pred range between the red vertical lines. c. Comparison of model performance on IEDB peptides for 3 human Class II disease-associated alleles (DRB1_0405, DRB1_1201, DRB1_1454) as defined by the AUROC for peptide sizes 22-36. orange, SWING Class II; magenta, SWING Mixed; green, MixMHC2Pred 2.0; gray, NetMHCIIpan 4.2.

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