Fig. 2: Histology mapping, depth-wise microstructural profiles and dimensionality reduction.

a, Sample slices and average 3D maps of histological features. Maps are averaged across depths and, where possible, samples. Numbered lines indicate the approximate locations shown on the corresponding boxes in b. b, Example of microstructural profile shapes from five evenly spaced bins across the proximal–distal axis of the BigBrain Merker stain map. Gray indicates points outside the gray matter mask. c, Correlation between microstructural profiles, concatenated across modalities, at each vertex (left). Dimensionality reduction into primary diffusion embedding components 1–3 (right). Scale bars are arbitrary unless indicated otherwise. max., maximum; min., minimum; mMPC, multimodal microstructural profile covariance.