Fig. 5: Multiomics data analysis using the Giotto Suite framework.
From: Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem
a, Schematic representation and workflow for multiomics integration of spatial transcriptomic datasets. b–e, 10x Genomics Human Tonsil dataset. Analysis at the RNA (b) and protein (d) levels, multiomics integration (c) and DWLS deconvolution (e) using a reference scRNA-seq were performed. f–h, Multiomics analysis of the spatial RNA ATAC–seq mouse embryo ME13 dataset. Spatial distribution of RNA (f), ATAC (g) and integrated modalities-based Leiden clusters (h) is presented. Panel a was created in BioRender.com. CD4_T, CD4 T cell; DWLS, dampened weighted least squares; FDC, follicular dendritic cell; GCBC, germinal center B cell; PDC, plasmacytoid dendritic cell; PC, plasma cell; preBC, pre-B cell; preTC, pre-T cell; NBC_MBC, naïve B cell and memory B cell.
