Fig. 1: Multi-omic profiling of DNA methylation and histone modifications with scEpi2-seq.
a, Overview of scEpi2-Seq workflow. Figure created with BioRender.com. b, Single-cell heatmaps of cut sites across three different histone modifications. Signals are aggregated per mark (top). c,d, Single-cell heatmap and line chart of distance between MNase cut sites with oscillations related to nucleosome positioning. Line indicates a LOESS smoothened curve of the underlying data points and error bands indicates the s.e. of the LOESS fit. e, Single-cell heatmaps of DNA methylation across three different histone modifications. Signals are aggregated per mark (top). f, Average methylation per mark with respect to distance from cut site.
