Fig. 2: Methylation maintenance resolved for histone marks and replication timing. | Nature Methods

Fig. 2: Methylation maintenance resolved for histone marks and replication timing.

From: Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance

Fig. 2

a, Scatter-plot of cell cycle reporter intensities for RPE-1 FUCCI cells. Color indicates neighbor-averaged methylation per cell. b, Heatmap of scEdU-seq signal intensity for a representative region of chromosome 1. Single cells (y axis) are ordered by S-Phase progression. c, Heatmap of normalized methylation across the cell cycle (left) and histogram of histone modification signal intensities (right). Rows are ordered by genomic replication timing (RT). d, Heatmap of normalized methylation for a representative region on chromosome 1. Rows are ordered based on cell-cycle progression. Data for most prevalent histone modification per bin are used to compute average methylation. Dashed line shows replication timing for the same region inferred from scEdU-seq.

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