Extended Data Fig. 3: Individual lever presses are species-typical and unaffected by the MC lesion. | Nature Neuroscience

Extended Data Fig. 3: Individual lever presses are species-typical and unaffected by the MC lesion.

From: The role of motor cortex in motor sequence execution depends on demands for flexibility

Extended Data Fig. 3

a, Average forelimb movement trajectories (scaled) for the left (L), center (C) and right (R) lever presses for all animals (n = 7) in the flexible task context. Each line denotes a different rat. Top row is the horizontal (left) and vertical (right) trajectories pre-lesion; bottom row is the trajectories post-lesion. b, Mean (left) and max (right) forelimb speed over single lever presses, before and after the lesion. Lines indicate individual rats (n = 7). P > 0.05, two-sided t-test. c, Correlation of the mean forelimb trajectory (horizontal and vertical) during a single lever-press, across levers (L, C or R) and rats (n = 7), giving us n = 3 × 7 samples. Each dot indicates a correlation between individual samples. Comparisons are made across mean forelimb trajectories pre-lesion (n = 210), post-lesion (n = 210) and between pre-lesion and post-lesion trajectories (n = 441). For all subpanels, *P < 0.05, two-sided paired t-test. n.s. signifies P > 0.05.

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