Extended Data Fig. 6: Sex differences in the normative growth curves of the functional connectome at global, system, and regional levels.
From: Human lifespan changes in the brain’s functional connectome
a, Sex-stratified growth curves for global functional metrics. The solid line represents the 50th centile, with the two surrounding dotted lines denoting the 95% confidence interval, which were estimated by bootstrapping 1,000 times. The subplots from left to right represent the global mean of the connectome, global variance of the connectome, and global system segregation, respectively. b, Sex-specific growth curves for system segregation in each network. The solid line represents the 50th centile, with the two surrounding dotted lines denoting the 95% confidence interval. c, Sex differences in the growth curves of regional-level FCS, where red colors indicate that the values of males are significantly higher than those of females, and blue colors denote that the values of females are significantly higher than those of males. Among the 4,609 vertices, 3,872 exhibited significant sex differences (p < 0.05, Benjamini-Hochberg FDR corrected). FCS, functional connectivity strength; VIS, visual; SM, somatomotor; DA, dorsal attention; VA, ventral attention; LIM, limbic; FP, frontoparietal; DM, default mode. M, male; F, female. **, p < 0.01, ***, p < 0.001, Benjamini-Hochberg FDR corrected. The exact p-values is provided in Supplementary Table 3.
