Extended Data Fig. 7: A series of sensitivity analyses for the validation of lifespan normative growth curves and growth rates of the functional connectome.
From: Human lifespan changes in the brain’s functional connectome
a, Global mean of the connectome. b, Global variance of the connectome. c, Global system segregation. d, System segregation in each network. These sensitive analyses included the validation of the potential effects of head motion using more strict head motion threshold (mean framewise displacement (FD) < 0.2 mm, N = 24,494), the impact of uneven sample and site distributions across ages using a balanced sampling strategy that ensures uniformity in participant and site numbers (N = 6,770, resampling 1,000 times), the reproducibility of the results using a split half approach (Nsubgroup1 = 16,663, Nsubgroup2 = 16,587), the potential effects of data samples using a bootstrap resampling analysis (1,000 times), and the potential effects of specific sites using a leave-one-site-out (LOSO) analysis. For the balanced resampling analysis, the figure showed the average of the 1,000 resampled median centile lines. For the bootstrapping resampling analysis, the figure showed the average of the 1,000 bootstrapped median centile lines. For the LOSO analysis, the figure displays the average of the 132 median centile lines. VIS, visual; SM, somatomotor; DA, dorsal attention; VA, ventral attention; LIM, limbic; FP, frontoparietal; DM, default mode; yr, year.
