Extended Data Fig. 8: Lifespan normative growth patterns of negative functional connectivity.
From: Human lifespan changes in the brain’s functional connectome
a, Global mean of negative functional connectivity by calculating averaged negative connectivity across all edges. The left panel shows the averaged median (50th) centile as a solid line, surrounded by the averaged 5th, 25th, 75th, and 95th centiles as dotted lines. In the right panel, the solid line illustrates the growth rate of the averaged median centile, with its 95% confidence interval highlighted by gray shaded areas. b, Global mean of negative connectivity by calculating averaged negative connectivity across only non-zero edges. The left panel shows the averaged median (50th) centile as a solid line, surrounded by the averaged 5th, 25th, 75th, and 95th centiles as dotted lines. In the right panel, the solid line illustrates the growth rate of the averaged median centile, with its 95% confidence interval highlighted by gray shaded areas. c, The median centiles (top panel) and their growth rates (bottom panel) for all vertices at several key age points. d, The lifespan growth axis of negative functional connectivity, represented by the first principal component (accounting for 53.5% of the variance) from a PCA on regional-level FCS curve. e, Based on the lifespan principal axis, all vertices across the brain were equally divided into 20 bins. The zero-centered curves of all vertices within each bin were averaged. The first vigintile (depicted in darkest blue) represents one pole of the axis, while the twentieth vigintile represents the opposite pole (depicted in darkest yellow). f, A strong negative correlation was observed between the lifespan principal growth axis and the sensorimotor-association (S-A) axis (r = -0.50, pspin < 0.0001, one-sided) (linear association shown with a 95% confidence interval). FCS, functional connectivity strength; PCA, principal component analysis; wk, week; yr, year.
