Extended Data Fig. 9: Lifespan normative growth patterns of regional system segregation of subcortical structures.
From: Human lifespan changes in the brain’s functional connectome
a, The subcortical parcellation (scale I) proposed by Tian et al.81, including eight regions: Hippocampus (HIP), Amygdala (AMY), Posterior thalamus (pTHA), Anterior thalamus (aTHA), Nucleus accumbens (NAc), Globus pallidus (GP), Putamen (PUT), Caudate nucleus (CAU). b, The left panel showed the normative growth curves of mean system segregation in the whole-subcortex. The median (50th) centile is represented by a solid line, while the 5th, 25th, 75th, and 95th centiles are indicated by dotted lines. The right panel showed the growth rates of mean system segregation in the whole-subcortex. The growth peak occurred at the third decade of life (32.1 years, 95% bootstrap confidence interval 31.0–33.2). The gray shaded areas represent the 95% confidence interval, which were estimated by bootstrapping 1,000 times. c, Normative growth curve (top panel, showed as centile lines) and growth rate (bottom panel, showed as the central line) of system segregation for each subcortical region. The gray shaded areas represent the 95% confidence interval. yr, year.
