Extended Data Fig. 2: Ant-134 administration into the dHPC does not alter Arc, Npas4 or c-Fos levels within the dDG. | Nature Neuroscience

Extended Data Fig. 2: Ant-134 administration into the dHPC does not alter Arc, Npas4 or c-Fos levels within the dDG.

From: Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time

Extended Data Fig. 2

Ant-134 (10 pmol in 0.5 µl) was administered unilaterally into one dHPC and scrambled control (Scr, 10 pmol in 0.5 µl) into the other dHPC, counterbalanced across animals, immediately after training on the dual-event inhibitory avoidance task. Ant-134 administration did not affect mRNA levels of several plasticity-related genes that are considered non-targets of miR-134 within the dDG 30 min later. mRNA levels are normalized to the scrambled-treated hemisphere (mean + s.e.m.) (n = 7, paired Student’s t-test: activity-regulated cytoskeleton-associated protein (Arc): t6 = 1.73, P = 0.13; neuronal PAS domain protein 4 (Npas4): t6 = 1.86, P = 0.11; c-Fos: t6 = 1.09, P = 0.32).

Back to article page