Extended Data Fig. 4: Overexpression of miR-134 in the dHPC induces an efficient down-regulation of CREB and BDNF mRNA levels within the dDG. | Nature Neuroscience

Extended Data Fig. 4: Overexpression of miR-134 in the dHPC induces an efficient down-regulation of CREB and BDNF mRNA levels within the dDG.

From: Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time

Extended Data Fig. 4

Mimic-134 (0.25 pmol in 0.5 µl) was administered unilaterally into one dHPC and non-target control (NT, 0.25 pmol in 0.5 µl) into the other dHPC, counterbalanced across animals, immediately after training on the dual-event inhibitory avoidance task. Mimic-134 administration resulted in a 6.60 ± 0.91 log2FC (mean ± s.e.m) increase in total-tissue miR-134 levels within the dDG 30 min later (n = 6, paired Student’s t-test: t5 = 7.26, P < 0.01). mRNA levels are normalized to the non-target-treated hemisphere (mean + s.e.m.) (n = 6, paired Student’s t-test: CREB: t5 = 3.22, P < 0.05; BDNF: t5 = 3.28, P < 0.05). *P < 0.05 vs non-target.

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