Supplementary Figure 6: Germline neutralization data.
From: Structural basis of broad ebolavirus neutralization by a human survivor antibody
(a-c) Neutralization of rVSVs bearing EBOV GP, BDBV GP, and SUDV GP, respectively, by wild-type ADI-15946 (black circles), heavy chain germline-revertant (HCIGL, gray squares), light chain germline-revertant (LCIGL; light blue triangles) and the HCIGL-LCIGL combination (purple diamonds). (d-f) Neutralization of rVSV bearing GPCL of EBOV, BDBV and SUDV, respectively, by the same ADI-15946 variants. (g) Neutralization of rVSV-EBOV GP bearing a W291R point mutation by wild-type and germline-revertant ADI-15946. For comparison, neutralization of rVSV-EBOV bearing uncleaved GP by wild-type ADI-15946 (orange open circles) is also shown. Virions bearing GPCL are better neutralized by wild-type ADI-15946 and its heavy chain germline-revertant (HCIGL; gray squares). (a-g) Mean±SD; n=6 biologically independent samples in each figure panel.
