Table 2 Brca1−/− intercrosses

From: Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice

Brca1+/−53bp1−/− × Brca1+/−53bp1−/−

Brca1

+/+

+/−

−/−

53bp1

+/+

−/−

−/−

Live pups (n = 209)

68 (52.25)

120 (104.5)

21 (52.25)

Brca1+/−Shld2−/− × Brca1+/−Shld2−/−

Brca1

+/+

+/−

−/−

Shld2

+/+

−/−

−/−

Live pups (n = 242)

89 (60.5)

153 (121)

0 (60.5)

Embryos, (E8.5–11.5) (n = 57)

15 (14.25)

32 (28.5)

10 (14.25)

  1. Summary of the frequency of live pups born or >E12.5 embryos genotyped from 53bp1−/−Brca1+/− or Shld2−/−Brca1+/− crosses.
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