Extended Data Fig. 3: Cryo-EM data processing and analysis focusing on the VO part.
From: Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure
(a) Workflow diagram illustrating the process to derive the final VO part Cryo-EM map. 3,264 micrographs were collected and processed for the cryo-EM reconstruction. (b) Fourier shell correlation (FSC) curves for the reconstructed Cryo-EM half-set maps and between the atomic model and full-set map. (c) Angular distribution plot. (d) Local resolution of the reconstructed map. The right panel provides a detailed view of the V-161 binding site at the interface of the c-ring and the a-subunit.
