Extended Data Fig. 7: H3K27me3 occupancy at active and inactive X chromosomes. | Nature Structural & Molecular Biology

Extended Data Fig. 7: H3K27me3 occupancy at active and inactive X chromosomes.

From: Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing

Extended Data Fig. 7

(A) Heatmaps of H3K27me3 occupancy in E11.5 and E12.5 female PGCs. Profile plots and their corresponding heatmaps centred on the transcription start sites (TSS) +/- 3 kb of all X-linked genes for H3K27me3 repressive histone marks. The purple-to-yellow gradient indicates low to high sum score of H3K27me3 in the corresponding regions clustered by k-mean =5 on total H3K27me3 at E11.5. Genome B6: Xa and Genome Cast: Xi. (B) Repartition of reactivation classes and silent genes in the different clusters, calculated by k-mean, based on their H3K27me3 occupancy at E11.5. Silent gene class has been characterised as genes silenced from both X chromosomes in all female PGC scRNA-seq. Numbers in pie charts are TSS.

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