Extended Data Fig. 6: Local shifts of bulged A between pre-1S and 1S.
From: Structural basis of circularly permuted group II intron self-splicing
a. Secondary structure, cryo-EM density map and model of D6 showing a 2-nt bulge (G126 and A127) in pre-1S, in which two base triples C100-A127-C538 and G101-C125-G220 were formed. b. Secondary structure, cryo-EM density map and model of D6 with bulged A127 interacting with G101-C125 in 1S. c-d. Analogous bulged A structure in c. canonical group II intron E.r. intron pre-1F (8T2S) and d. yeast S.c. spliceosome (7B9V). Blue dashed lines indicate hydrogen bonds.
