Fig. 6: Model of domain dispositions presenting potent epitopes of GPI-anchored Pfs48/45. | Nature Structural & Molecular Biology

Fig. 6: Model of domain dispositions presenting potent epitopes of GPI-anchored Pfs48/45.

From: Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual

Fig. 6

a–c, Models of Pfs48/45 derived from the Pfs48/45:10D8 cocrystal structure (PDB ID: 7ZXF) (a), the Pfs48/45-scTB31F:RUPA-44:RUPA-58:RUPA-154 complex (b), and the Pfs48/45-scTB31F:RUPA-44:RUPA-58 complex (c) are depicted, with a carboxy terminal linker connecting D3 to GPI anchor (black). The plasma membrane is shown in gray. D1, D2, and D3 are colored light blue, blue, and navy, respectively. Epitopes of TB31F (red), RUPA-58 (white), RUPA-44 (orange), and RUPA-71 (green) are accessible in all above conformations; the epitope of RUPA-154 (yellow) is not accessible in the conformation of the Pfs48/45-scTB31F:RUPA-44:RUPA-58 complex. The overlay between epitopes of RUPA-58 and RUPA-71 is depicted in light green.

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