Extended Data Fig. 6: Conformational changes of TM2 and TM4 induced by the S136P mutation. | Nature Structural & Molecular Biology

Extended Data Fig. 6: Conformational changes of TM2 and TM4 induced by the S136P mutation.

From: Gating mechanism of the two-pore-domain potassium channel THIK1

Extended Data Fig. 6

a-c, View from the membrane plane showing one TM2 from THIK1WT, THIK1S136P, and both structures overlaid. The dashed line in (c) indicates the central axis of the helix, and the rotation degree is labeled. d, Overlaid structures of THIK1WT and THIK1S136P. The dashed arrows indicate the motion directions of TM2 and TM4.

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