Extended Data Fig. 4: Characteristics of the TXNL1-bound proteasome.
a, Structure of the TXNL1-bound proteasome with TXNL1, PSMD14, and AAA-ATPase subunits colored as in Fig. 1bb, Clipped side view of the AAA-ATPase ring (top), colored by subunit, with the position of aromatic pore loop residues shown in spheres and substrate density in blue. Scheme (bottom) depicting the configuration and nucleotide (T – ATP, D – ADP)-bound states of the ATPase subunits relative to the substrate (blue). c, Superposition of the AAA-ATPase ring with that in the ED2 state of the human proteasome (PDB 6MSK; transparent dark blue; middle) or the 4D state of the yeast proteasome (PDB 6EF3; transparent dark purple, right). d, Map density (mesh) and model of the nucleotide binding site in the indicated AAA-ATPase subunit (from top to bottom: PSMC2, PSMC1, PSMC5, PSMC4, PSMC6, and PSMC3).
