Extended Data Fig. 2: Characterization of the effect of MDK on Aβ fibrillation.
From: Midkine attenuates amyloid-β fibril assembly and plaque formation
a, Diagram of the secondary nucleation model illustrating Aβ assembly. The rate constants (k+ and k2) are defined with units, reflecting their dependency on protein concentration and time. b-c, Analysis of Aβ40 and Aβ42 elongation constants (k+) by fitting the ThT data. d, Effect of MDK (0-3 µM) on Aβ40 fibrillation kinetics (n = 3 replicates, averaged data shown). e, Effect of MDK (0-3 µM) on Aβ42 fibrillation kinetics (n = 3 replicates, averaged data shown). f, Time course CD spectra of Aβ40 alone (0-24 h). g, Time course CD spectra of Aβ40 with MDK (0-24 h). h, Time course CD spectra of Aβ42 alone (0-24 h). i, Time course CD spectra of Aβ42 with MDK (0-24 h). Full statistical information is in Source Data Statistics.
