Fig. 1: Cryo-EM structure of the SEAC–EGOC supercomplex.
From: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
a, The 2D class averages of the final particles used in the reconstruction. The arrows show the blurry density corresponding to the EGOC. b, A composite cryo-EM map colored according to subunits. c, A model of the SEAC–EGOC supercomplex. The predicted orientation relative to the vacuole membrane is shown on the right. d, A schematic representation of the SEAC and EGOC subunits. C-ter, C-terminal domain; NTD, N-terminal domain; CRD, C-terminal Roadblock domain; RWD, domain found in RING finger-, WD-repeat- and yeast DEAD (DEXD)-like helicase-containing proteins; DIM, domain-invasion motif.
