Extended Data Fig. 4: Comparison between unbound and EGOC-bound SEAC structures.
From: Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex
a, Structure of the unbound SEAC (PDB: 8adl)11. b, Structure of the EGOC-bound SEAC. Arrows indicate a small opening of the wings relative to the core compared to the unbound structure. c, Comparison of the relative position of the SEACwing between unbound (grey) and EGOC-bound SEAC. The wing rotates around a pivot on Npr3-Sea4, which causes a displacement of the active site of ~11 Å (distance between Npr2 arginine finger in both models). Models were superimposed on the Sea4 copies that form the back interface, which is adjacent to the wings and interacts with Npr3. d, Comparison of the superimposed SEACwing between unbound and EGOC-bound SEAC. There is a small shift in Sea1 that serves to accommodate Gtr2.
