Supplementary Figure 7: Geometrically precise control of DOS structures.

a, A user-specified DOS nanopore with the smallest diameter down to sub-10 nanometer. From left to right panel: design, AFM images for pure DNA origami, class averaged TEM images, and size distribution of silica nanopore measured from raw TEM images, respectively. Histograms of three different pore sizes were normalized and fitted to Gaussian distribution curves (light blue), and the red dashes indicated direct measurements of the pore sizes from class averaged TEM images. b, DOS-diatom nanostructures. From left to right panel: the design model of a DNA origami template, AFM images before and after silicification, and the averaged TEM image of a DOS-diatom nanostructure, respectively. Scale bars, 50 nm. All unmarked units refer to nm. Nature. 2018. Vol. 559, 593–598. Copyright Nature Publishing Group.