Supplementary Fig. 4: Effect of microRNA clusters on common targets.

Representative western blot from G34 GBM cells after stable expression of either negative control, single microRNAs or their combination by lentiviral infection. SP1 and JAG1 are GBM-relevant oncogenes that are independently targeted by each one of the three microRNAs. While each microRNA, as expected, decreases the level of both proteins, the combination of microRNAs does not further increase the downregulation obtained by single targeting. (Adapted from Bhaskaran et al.¹³ under a Creative Commons Attribution 4.0 license (https://creativecommons.org/licenses/by/4.0/legalcode).