Extended Data Fig. 1: Purified brain EVs fixed with PFA and stained with uranyl acetate show a distinctive cup-shape morphology. | Nature Protocols

Extended Data Fig. 1: Purified brain EVs fixed with PFA and stained with uranyl acetate show a distinctive cup-shape morphology.

From: Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues

Extended Data Fig. 1

Representative photomicrograph of sucrose fraction c brain EVs isolated from a 12-month-old female mouse and visualized after negative stain. Note the cup shape of fixed EVs and the absence of contaminating material. Scale bar, 200 nm. All animal procedures were performed following the National Institutes of Health guidelines with approval from the Institutional Animal Care and Use Committee at the Nathan S. Kline Institute for Psychiatric Research.

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