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Spatial multiomics

Gene expression and chromatin state mapped in space

Now a protocol enables simultaneous measurement of gene expression and chromatin state in intact tissues, unlocking the relationship between tissue architecture and gene regulation.

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Fig. 1: Simultaneous barcoding of transcripts and chromatin using microfluidics.

Timm Häneke

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Correspondence to Enric Llorens-Bobadilla.

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E.L.-B. is a scientific consultant for 10X Genomics.

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Llorens-Bobadilla, E. Gene expression and chromatin state mapped in space. Nat Protoc 20, 2369–2371 (2025). https://doi.org/10.1038/s41596-025-01151-x

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