Table 2 Average values of selected morphological features for each group of five spheroids considered for each condition.

From: Single-cell light-sheet fluorescence 3D images of tumour-stroma spheroid multicultures

Time point

Multiculture spheroids

Diameter [µm]

Perimeter [µm]

Area [µm2]

Volume [µm3]

Circularity [−]

Sphericity [−]

24 h

T-47D (A)

174

713

24376

2574743

0.85

0.77

48 h

T-47D (A)

162

734

20564

1733780

0.76

0.69

96 h

T-47D (A)

167

680

21842

2218002

0.83

0.77

24 h

dox-T-47D (A+)

174

815

24412

2146463

0.74

0.68

48 h

dox-T-47D (A+)

161

673

20818

1830226

0.79

0.76

96 h

dox-T-47D (A+)

141

604

15758

1034803

0.76

0.74

24 h

A375 (B)

185

882

24376

2328160

0.72

0.66

48 h

A375 (B)

187

827

20564

2834749

0.78

0.72

96 h

A375 (B)

161

689

21842

1932300

0.79

0.74

24 h

dox-A375 (B+)

147

728

16989

1005072

0.69

0.64

48 h

dox-A375 (B+)

146

679

16828

1210798

0.73

0.68

96 h

dox-A375 (B+)

137

610

15004

1143153

0.75

0.72

24 h

MG-63 (C)

171

791

27817

1873964

0.78

0.71

48 h

MG-63 (C)

178

767

27848

1989199

0.79

0.73

96 h

MG-63 (C)

178

730

20451

2523054

0.82

0.77

24 h

dox-MG-63 (C+)

146

631

16991

1408364

0.81

0.75

48 h

dox-MG-63 (C+)

143

583

16171

1315481

0.81

0.78

96 h

dox-MG-63 (C+)

140

556

15461

1220975

0.83

0.79