Figure 1 | Scientific Reports

Figure 1

From: NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration

Figure 1

NKX2-1-AS1 expression patterns in human non-small cell lung carcinoma (NSCLC). (A) Schematic representation of the relative chromosomal location of NKX2-1-AS1 lncRNA and adjacent NKX2-1 protein coding-gene in human chromosomal region 14q13.3. Arrows indicate direction of transcription. Boxes indicate exons, dotted lines indicate introns and colored boxes indicate coding regions. (B) Levels of expression of NKX2-1-AS1 and NKX2-1 in NSCLCs (SCC = squamous cell carcinoma; and AC = adenocarcinoma) relative to their corresponding non-tumor control determined by qPCR (n = 8; *p < 0.03). (C) Correlation plot of the expression of NKX2-1-AS1 and NKX2-1 determined by qPCR in the above tumors and their corresponding non-tumor specimens analyzed in this study. (D) Amplification status of the NKX2-1-AS1 locus determined by qPCR of genomic DNA and expressed as copy number of the NKX2-1-AS1 gene per genome plotted relative to NKX2-1-AS1 expression level in each sample (n = 12).

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