Table 3 Apparent and bias-corrected measures of discrimination and classification of the models based on cytokines and citokine ratios for both smokers and non-smokers.
Model | Smoking status | AUC | ACC (%) | Sensitivity (%) | Specificity (%) | Positive Predictive Value (%) | Negative Predictive Value (%) |
|---|---|---|---|---|---|---|---|
IL1alpha | Smoker | 0.966 0.951 | 92.5 89.4 | 100.0 97.1 | 69.2 65.8 | 91.1 89.9 | 100.0 92.6 |
Non-smoker | 0.959 0.958 | 93.5 92.4 | 87.5 85.8 | 96.7 96.0 | 93.5 92.1 | 93.7 92.8 | |
IL1beta | Smoker | 0.968 0.945 | 94.4 90.7 | 97.5 96.6 | 84.6 71.1 | 95.2 91.9 | 92.3 88.8 |
Non-smoker | 0.944 0.943 | 94.6 94.1 | 90.6 89.5 | 96.7 96.5 | 93.7 93.4 | 95.2 94.6 | |
IL17A | Smoker | 0.940 0.912 | 92.5 90.3 | 95.1 93.9 | 84.6 79.1 | 95.2 93.6 | 85.7 82.1 |
Non-smoker | 0.914 0.914 | 88.1 86.8 | 78.1 76.1 | 93.4 92.5 | 86.2 84.3 | 89.2 88.2 | |
IL1alpha/IL2 | Smoker | 0.878 0.868 | 85.1 81.1 | 100.0 99.0 | 38.4 29.5 | 83.6 80.2 | 100.0 99.0 |
Non-smoker | 0.911 0.905 | 88.1 85.1 | 84.3 80.0 | 90.1 88.6 | 81.8 78.6 | 91.6 89.2 | |
IL1beta/IL2 | Smoker | 0.906 0.896 | 92.5 88.7 | 95.1 94.7 | 84.6 76.3 | 95.1 91.1 | 85.7 82.1 |
Non-smoker | 0.886 0.881 | 84.9 79.5 | 81.2 70.6 | 86.8 84.3 | 76.4 72.3 | 89.8 84.1 | |
IL17A/L2 | Smoker | 0.955 0.948 | 92.5 87.2 | 100.0 98.6 | 69.2 51.4 | 91.1 86.5 | 100.0 95.7 |
Non-smoker | 0.857 0.834 | 80.6 72.9 | 87.5 81.7 | 77.0 68.3 | 66.6 54.3 | 92.3 89.1 |
