Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-47573-y, published online 08 August 2019
In Figure 9A, the connection between S6K1 and Rictor was switched with that between Rictor and mTORC2. The correct Figure 9 appears below as Figure 1.
Summary of our model on the molecular action of YM155 in prostate cancer cells. Panel A represents the overall molecular steps in which our model supports that YM155 rapidly promotes the activation of AMPK and subsequent inactivation of mTORC1 and suppression of cap-dependent translation of proteins involved in cell cycle and survival. This model also illustrates that YM155 additionally promotes the loss of AMPKα1 or AMPKα2, and that such loss counter-intuitively promotes growth arrest and cell death. Panel B is a simplified version of panel A.
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Danielpour, D., Gao, Z., Zmina, P.M. et al. Author Correction: Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK. Sci Rep 9, 14826 (2019). https://doi.org/10.1038/s41598-019-51007-0
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DOI: https://doi.org/10.1038/s41598-019-51007-0
