Table 1 Diagnostic performance indicators used in the comparative analysis.

From: The 2018 periodontitis case definition improves accuracy performance of full-mouth partial diagnostic protocols

Sensitivity (True positive rate)

TP/(TP + FN)

Proportion positive test results among diseased

Specificity (True negative rate)

TN/(TN + FP)

Proportion negative test results among the “healthy”

Accuracy

(TP + TN)/(TP + TN + FP + FN)

Proportion of correctly identified subjects

Precision - Positive Predictive Values (PPV)

TP/(TP + FP)

—

Youden’s index

Sensitivity + Specificity − 1

Measures the performance of a dichotomous diagnostic test

DOR

(TP/FN)/(FP/TN)

Ratio of the odds of positivity in disease relative to the odds of positivity in the non-diseased

DOR (95% CI)

95% CI = log DOR ± 1.96SE(log DOR), where \(SE(logDOR)=\sqrt{\frac{1}{TP}+\frac{1}{TN}+\frac{1}{FP}+\frac{1}{FN}}\)

—

F1 Score

2TP/(2TP+FP+FN)

Harmonic mean of precision and sensitivity

Matthews Correlation Coefficient (MCC)

(TP x TN - FP x FN)/\(\sqrt{(({\rm{TP}}+{\rm{FP}}){\rm{x}}({\rm{TP}}+{\rm{FN}}){\rm{x}}({\rm{TN}}+{\rm{FP}}){\rm{x}}({\rm{TN}}+{\rm{FN}})}\)

Measure of quality of binary classifications

  1. 95% CI – 95% Confidence Interval; DOR – Diagnostic Odds Ratio; FN – False Negative, FP – False Positive; SE – Standard Error; TN – True Negative; TP –True Positive. Adapted from 16.
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