Table 1 Results of univariable Mendelian randomization analyses of sex-combined and sex-specific associations between urinary sodium secretion with body mass, shape and composition outcomes.

From: Causal associations between urinary sodium with body mass, shape and composition: a Mendelian randomization study

Outcome	SNPs	N	R² (%)	F statistic	Inverse-variance weighed method		Weighted median methods		MR-Egger method
Outcome	SNPs	N	R² (%)	F statistic	Beta (95% CI)	P for beta	Beta (95% CI)	P for beta	Beta (95% CI)	P for beta	P for Egger intercept
Sex-combined
BMI	34	322,154	4.227	579.157	0.392 (0.149, 0.634)	0.002	0.542 (0.287, 0.797)	< 0.001	− 0.193 (− 1.387, 1.001)	0.751	0.327
HC	35	211,088	4.036	536.146	0.247 (− 0.014, 0.509)	0.064	0.215 (− 0.080, 0.510)	0.153	− 0.286 (− 1.703, 1.131)	0.693	0.453
WC	37	211,088	4.546	574.298	0.508 (0.228, 0.789)	< 0.001	0.526 (0.231, 0.822)	< 0.001	− 0.041 (− 1.452, 1.370)	0.954	0.436
WHR	38	211,088	4.703	579.443	0.449 (0.220, 0.677)	< 0.001	0.511 (0.241, 0.780)	< 0.001	− 0.072 (− 1.256, 1.111)	0.905	0.379
BMI-adjusted HC	39	211,088	4.953	596.237	− 0.122 (− 0.289, 0.046)	0.154	− 0.102 (− 0.347, 0.144)	0.417	0.305 (− 0.519, 1.130)	0.468	0.300
BMI-adjusted WC	43	211,088	5.565	611.484	0.136 (− 0.045, 0.317)	0.140	0.110 (− 0.115, 0.336)	0.338	0.610 (− 0.266, 1.486)	0.173	0.279
BMI-adjusted WHR	40	211,088	5.089	598.136	0.290 (0.101, 0.478)	0.003	0.310 (0.087, 0.532)	0.006	0.379 (− 0.636, 1.394)	0.464	0.861
BF percentage	41	89,297	5.207	597.795	0.475 (0.208, 0.741)	< 0.001	0.335 (− 0.008, 0.679)	0.055	0.028 (− 1.309, 1.365)	0.967	0.504
WLM	40	38,292	4.942	579.909	0.639 (− 0.579, 1.857)	0.304	0.831 (− 0.832, 2.495)	0.327	− 3.710 (− 10.054, 2.634)	0.252	0.171
ALM	40	28,330	4.942	579.909	− 0.233 (− 1.008, 0.542)	0.556	0.034 (− 1.017, 1.086)	0.949	− 3.363 (− 7.259, 0.533)	0.091	0.108
Male-specific
BMI	38	152,882	4.731	583.146	0.417 (0.113, 0.720)	0.007	0.610 (0.289, 0.931)	< 0.001	0.378 (− 1.117, 1.874)	0.620	0.959
HC	37	93,480	4.522	571.095	0.197 (− 0.155, 0.549)	0.272	0.196 (− 0.193, 0.584)	0.323	1.451 (− 0.394, 3.297)	0.123	0.175
WC	35	93,480	4.299	572.741	0.476 (0.157, 0.796)	0.003	0.584 (0.175, 0.993)	0.005	0.646 (− 1.078, 2.370)	0.463	0.844
WHR	38	93,480	4.775	588.810	0.607 (0.315, 0.899)	< 0.001	0.399 (0.043, 0.755)	0.028	− 1.013 (− 2.499, 0.472)	0.181	0.029
BMI-adjusted HC	38	93,480	4.723	582.123	− 0.396 (− 0.699, − 0.092)	0.011	− 0.252 (− 0.625, 0.120)	0.184	0.727 (− 0.848, 2.303)	0.366	0.155
BMI-adjusted WC	40	93,480	5.133	603.571	0.097 (− 0.135, 0.329)	0.411	0.015 (− 0.313, 0.344)	0.927	0.802 (− 0.382, 1.987)	0.184	0.234
BMI-adjusted WHR	40	93,480	5.133	603.571	0.339 (0.114, 0.564)	0.003	0.230 (− 0.076, 0.536)	0.141	− 0.332 (− 1.489, 0.824)	0.574	0.246
BF percentage	41	44,429	5.207	597.795	0.617 (0.270, 0.963)	< 0.001	0.134 (− 0.322, 0.590)	0.564	− 0.410 (− 2.117, 1.298)	0.638	0.229
Female-specific
BMI	36	171,963	4.452	577.461	0.571 (0.295, 0.848)	< 0.001	0.552 (0.243, 0.860)	< 0.001	0.011 (− 1.421, 1.443)	0.988	0.434
HC	37	116,742	4.669	590.581	0.455 (0.157, 0.752)	0.003	0.492 (0.168, 0.815)	0.003	0.747 (− 0.877, 2.371)	0.367	0.720
WC	33	116,742	4.249	600.039	0.480 (0.190, 0.769)	0.001	0.46 (0.125, 0.795)	0.007	− 0.030 (− 1.558, 1.498)	0.969	0.505
WHR	37	116,742	4.602	581.688	0.395 (0.115, 0.676)	0.006	0.501 (0.196, 0.805)	0.001	0.742 (− 0.825, 2.309)	0.353	0.659
BMI-adjusted HC	38	116,742	4.822	594.864	− 0.032 (− 0.239, 0.176)	0.766	− 0.096 (− 0.384, 0.192)	0.514	0.597 (− 0.488, 1.681)	0.281	0.248
BMI-adjusted WC	40	116,742	5.212	613.340	0.190 (− 0.027, 0.406)	0.085	0.288 (− 0.001, 0.576)	0.050	0.528 (− 0.585, 1.642)	0.352	0.544
BMI-adjusted WHR	38	116,742	4.659	573.819	0.249 (0.027, 0.472)	0.028	0.264 (− 0.028, 0.556)	0.076	1.057 (− 0.185, 2.298)	0.095	0.196
BF percentage	42	45,525	5.319	596.862	0.348 (0.027, 0.669)	0.034	0.414 (− 0.010, 0.838)	0.056	0.724 (− 0.882, 2.330)	0.377	0.639

BMI body mass index, WC waist circumference, HC hip circumference, WHR waist-to-hip ratio, BF body fat, ALM appendicular lean mass, WLM whole body lean mass, SNP single nucleotide polymorphism, R² (%) the percentage of exposure variance explained by SNPs, 95% CI 95% confidence interval.

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Table 1 Results of univariable Mendelian randomization analyses of sex-combined and sex-specific associations between urinary sodium secretion with body mass, shape and composition outcomes.

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