Table 2 Results of multivariable Mendelian randomization analysis (inverse-variance weighted method) adjusted for estimated glomerular filtration rate.

From: Causal associations between urinary sodium with body mass, shape and composition: a Mendelian randomization study

Outcome

SNPs

N

R2 (%)

F statistic

Inverse-variance weighted method

MR-Egger method

P for heterogeneity between sexes

Beta (95% CI)

P for beta

Beta (95% CI)

P for beta

P for Egger intercept

Sex-combined

BMI

34

322,154

4.227

579.157

0.406 (0.202, 0.610)

 < 0.001

0.319 (− 0.736, 1.373)

0.554

0.868

0.439

HC

35

211,088

4.036

536.146

0.299 (0.055, 0.544)

0.017

0.449 (− 0.998, 1.896)

0.543

0.837

0.768

WC

37

211,088

4.546

574.298

0.533 (0.283, 0.783)

 < 0.001

0.486 (− 0.821, 1.794)

0.466

0.943

0.359

WHR

38

211,088

4.703

579.443

0.385 (0.145, 0.624)

0.002

− 0.371 (− 1.567, 0.825)

0.543

0.207

0.225

BMI-adjusted HC

39

211,088

4.953

596.237

− 0.094 (− 0.259, 0.070)

0.261

0.277 (− 0.523, 1.078)

0.497

0.353

0.073

BMI-adjusted WC

43

211,088

5.565

611.484

0.121 (− 0.045, 0.287)

0.154

0.719 (− 0.078, 1.516)

0.077

0.133

0.723

BMI-adjusted WHR

40

211,088

5.089

598.136

0.222 (0.029, 0.416)

0.025

0.052 (− 0.979, 1.083)

0.921

0.742

0.351

BF percentage

41

89,297

5.207

597.795

0.471 (0.198, 0.744)

0.001

0.024 (− 1.331, 1.379)

0.972

0.509

0.242

WLM

40

38,292

4.942

579.909

0.633 (− 0.587, 1.853)

0.309

− 3.705 (− 10.074, 2.665)

0.254

0.174

NA

ALM

40

28,330

4.942

579.909

− 0.246 (− 1.029, 0.536)

0.537

− 3.276 (− 7.231, 0.679)

0.104

0.126

NA

Male-specific

BMI

38

152,882

4.731

583.146

0.443 (0.163, 0.724)

0.002

0.755 (− 0.650, 2.159)

0.292

0.657

 

HC

37

93,480

4.522

571.095

0.228 (− 0.102, 0.557)

0.176

2.204 (0.492, 3.915)

0.012

0.021

 

WC

35

93,480

4.299

572.741

0.526 (0.238, 0.813)

 < 0.001

1.335 (− 0.241, 2.911)

0.097

0.306

 

WHR

38

93,480

4.775

588.810

0.598 (0.300, 0.896)

 < 0.001

− 1.020 (− 2.522, 0.482)

0.183

0.032

 

BMI-adjusted HC

38

93,480

4.723

582.123

− 0.368 (− 0.673, − 0.063)

0.018

0.693 (− 0.879, 2.266)

0.388

0.178

 

BMI-adjusted WC

40

93,480

5.133

603.571

0.079 (− 0.156, 0.314)

0.508

0.784 (− 0.402, 1.969)

0.195

0.235

 

BMI-adjusted WHR

40

93,480

5.133

603.571

0.321 (0.094, 0.548)

0.006

− 0.346 (− 1.503, 0.811)

0.557

0.249

 

BF percentage

41

44,429

5.207

597.795

0.622 (0.268, 0.976)

0.001

− 0.406 (− 2.135, 1.323)

0.645

0.234

 

Female-specific

BMI

36

171,963

4.452

577.461

0.594 (0.333, 0.855)

 < 0.001

0.361 (− 1.034, 1.755)

0.612

0.739

 

HC

37

116,742

4.669

590.581

0.437 (0.135, 0.739)

0.005

0.710 (− 0.926, 2.345)

0.395

0.740

 

WC

33

116,742

4.249

600.039

0.464 (0.170, 0.758)

0.002

− 0.053 (− 1.592, 1.485)

0.946

0.502

 

WHR

37

116,742

4.602

581.688

0.337 (0.039, 0.636)

0.027

0.471 (− 1.184, 2.125)

0.577

0.872

 

BMI-adjusted HC

38

116,742

4.822

594.864

− 0.028 (− 0.240, 0.184)

0.796

0.598 (− 0.501, 1.697)

0.286

0.256

 

BMI-adjusted WC

40

116,742

5.212

613.340

0.135 (− 0.067, 0.336)

0.190

0.430 (− 0.594, 1.453)

0.411

0.564

 

BMI-adjusted WHR

38

116,742

4.659

573.819

0.170 (− 0.052, 0.391)

0.133

0.702 (− 0.534, 1.938)

0.266

0.391

 

BF percentage

42

45,525

5.319

596.862

0.334 (0.007, 0.662)

0.045

0.713 (− 0.908, 2.334)

0.388

0.640

 
  1. BMI body mass index, WC waist circumference, HC hip circumference, WHR waist-to-hip ratio, BF body fat, ALM appendicular lean mass, WLM whole body lean mass, SNP single nucleotide polymorphism, Ry(%) the percentage of exposure variance explained by SNPs, 95% CI 95% confidence interval, NA not applicable.
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