Scientific Reports

Table 1 Optimization of the reaction conditions^a.

From: Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides


Entry	X	Solvent	Base (equiv.)	Yield^b (%)
1	Br	CH₂Cl₂	K₂CO₃ (1.2)	71
2	Br	CHCl₃	K₂CO₃ (1.2)	80
3	Br	Et₂O	K₂CO₃ (1.2)	62
4	Br	DMSO	K₂CO₃ (1.2)	26
5	Br	toluene	K₂CO₃ (1.2)	37
6	Br	CHCl₃	Na₂CO₃ (1.2)	89
7	Br	CHCl₃	NaOH (1.2)	48
8	Br	CHCl₃	t-BuOK (1.2)	38
9	Br	CHCl₃	Et₃N (1.2)	20
10	Br	CHCl₃	Na₂CO₃ (1.3)	91
11^c	Br	CHCl₃	Na₂CO₃ (1.3)	94
12^c	Cl	CHCl₃	Na₂CO₃ (1.3)	83

^aReaction conditions: 1a (0.40 mmol), 2a (0.48 mmol), solvent (4 mL), base. ^bYield of isolated product. ^cThe ratio of 1a or 1aʹ and 2a is 1:1.3. DMSO: dimethyl sulfoxide.

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