Table 1 Characteristics of studied subjects.
Age group/years | NODAT | CNTRL | ||
|---|---|---|---|---|
N | % | N | % | |
< 40 | 28 | 18.1 | 98 | 63.2 |
40–60 | 80 | 52.0 | 45 | 29.1 |
> 60 | 46 | 29.9 | 12 | 7.7 |
Donor mean age/years | 34.4 ± 9.1 | 34.7 ± 8.8 | ||
Nationality | ||||
Kuwaiti | 76 | 49.4 | 93 | 60.0 |
Non-Kuwaiti | 78 | 50.6 | 62 | 40.0 |
Patient sex(male/female) | 107/47 | 112/43 | ||
Original kidney disease | ||||
Idiopathic | 42 | 27.3 | 33 | 21.3 |
Glomerulonephritis | 50 | 32.5 | 69 | 44.5 |
Hypertension | 10 | 6.5 | 9 | 5.8 |
Urological | 10 | 6.5 | 14 | 9.0 |
Others | 42 | 27.2 | 30 | 19.3 |
Virology | +ve/−ve | +ve/−ve | ||
HCV | 12/142 | 2/153 | ||
CMV IgM | 1/153 | 5/150 | ||
IgG | 153/0 | 148/5 | ||
Dialysis type | ||||
Hemodialysis | 118 | 76.6 | 121 | 78.0 |
Peritoneal dialysis | 16 | 10.4 | 14 | 9.1 |
Preemptive | 20 | 13.0 | 20 | 12.9 |
Pre-transplant co-morbidities Hypertension | 123 | 87.9 | 117 | 81.2 |
Pre-transplant TB exposure | 41 | 26.6 | 41 | 26.5 |
Ischemic heart disease | 19 | 14.0 | 13 | 9.0 |
Bone disease | 28 | 20.4 | 27 | 19.3 |
Anemia | 41 | 30.8 | 39 | 28.5 |
Hyperlipidemia | 7 | 5.3 | 6 | 4.3 |
Donor type | ||||
Live related | 132 | 85.7 | 125 | 80.7 |
Cadaveric | 22 | 14.3 | 30 | 19.3 |
Mean HLA mismatch | ||||
A locus | 1.10 ± 0.62 | 1.04 ± 0.63 | ||
B locus | 1.53 ± 0.98 | 1.22 ± 0.68 | ||
DR locus | 1.02 ± 0.71 | 0.97 ± 0.68 | ||
Total | 3.44 ± 1.46 | 3.26 ± 1.56 | ||
Induction immunosuppression | ||||
None | 20 | 13.0 | 11 | 7.1 |
IL2 receptor blocker (simulect) | 34 | 22.1 | 30 | 19.4 |
Anti-thymocyte globulin | 47 | 30.5 | 69 | 44.5 |
Others | 53 | 34.4 | 45 | 29.0 |
Type of immunosuppression: | ||||
Cyclosporine based | 82 | 53.9 | 63 | 42.0 |
Tacorlimus based | 64 | 42.1 | 82 | 54.7 |
Steroid free | 2 | 1.3 | 4 | 2.7 |
CNI free | 4 | 2.6 | 1 | 0.7 |
Graft function | ||||
Immediate | 90 | 58.4 | 94 | 60.6 |
Slow graft function | 21 | 13.6 | 36 | 23.2 |
Delayed graft function | 9 | 5.8 | 6 | 3.9 |
Unknown | 34 | 22.1 | 19 | 12.3 |
Basal BMI (mean ± SD) | 28.07 ± 5.58 | 26.11 ± 7 | ||
Last BMI(mean ± SD) | 29.92 ± 5.37 | 29.04 ± 6.2 | ||
Mean rejection episodes | 1.32 ± 0.47 | 1.47 ± 0.66 | ||
Graft outcome | ||||
Functioning | 140 | 91 | 145 | 94 |
Failed | 12 | 8 | 6 | 4 |
Lost follow up | 3 | 1 | 4 | 3 |
Patient outcome | ||||
Living | 150 | 97 | 151 | 97 |
Dead | 2 | 1 | 0 | |
Lost follow up | 2 | 1 | 4 | 3 |
Basal fasting blood sugar | 9.5 ± 1.4 | 4.5 ± 0.65 | ||
Basal HbA1C | 6.96 ± 1.5 | 5.2 ± 0.46 | ||
