Table 5 Selected (4) top hits based on percent identity and e-value for time course cluster analysis from intermittent hypoxia trials with expression trends shown over the 42 h of the experiment (from left to right).
Cluster | UniProt hit | Homolog name | Function |
|---|---|---|---|
1 280 features | HAAF | Hemagglutinin/amoebocyte aggregation | Trigger aggregation of amebocytes and erythrocytes |
| FRAS1 | Extracellular matrix protein fras1 | Morphogenesis of epithelium |
NU5M | NADH-ubiquinone oxidoreductase 5 | Metabolism | |
HSP7C | Heat shock cognate 71 | Protein chaperone in many processes | |
2 | DDX18 | ATP-dependent RNA helicase | Metabolism |
86 features | CP4F1 | Cytochrome P450 4F1 | Heme-binding |
| RL13A | 60 s Ribosomal protein L13a | Translation |
MEGF6 | Multiple epidermal growth factor | Calcium ion binding | |
3 | CP270 | Cytochrome P450 C270 | Heme-binding |
205 features | NTCP2 | Ileal sodium cotransporter | Sodium ion transport |
| CALM | Calmodulin | Calcium-mediated signaling |
HPGDS | Hematopoeitic prostaglandin D synthase | Protein homodimerization activity | |
4 157 features | POSTN | Periostin | Heparin-binding and cell adhesion |
| NRG | Neuroglian | Developmental protein |
SLO1 | Calcium-activated potassium channel | Potassium ion transport | |
PDCD6 | Programmed cell death protein 6 | Regulation of angiogenesis | |
5 258 features | FIBP | Acidic fibroblast growth factor intracellular-binding protein B | May help in laterality development |
| UBP19 | Ubiquitin carboxyl-terminal hydrolase 19 | Hsp90 protein binding |
RFA1 | Replication protein A 70 kDa DNA-binding subunit | DNA repair and telomere maintenance | |
HEM6 | Oxygen-dependent coproporphyrinogen-III oxidase | Heme/porphyrin biosynthesis | |
6 267 features | OTOP2 | Otoperin | Hydrogen ion transport |
| PRDX1 | Peroxiredoxin-1 | Cell protection against oxidative stress |
SQSTM | Sequestosome-1 | Ubiquitin-binding | |
GEPRP | Glycine, glutamate and proline-rich protein | Peptidoglycan catabolic process | |
7 149 features | FOLR1 | Folate receptor alpha | Embryonic development and cell proliferation |
| MLRA | Myosin regulatory chain A | Muscle protein |
FLNA | Filamin-A | Angiogenesis/blood vessel remodeling | |
PON2 | Arylesterase 2 | Response to oxidative stress | |
KCRT | Creatine kinase | ATP-binding | |
8 | TSP4 | Thrombospondin-4 | Cell adhesion and growth factor |
110 features | TENS1 | Tensin-1 | Actin-binding |
| S40A1 | Solute carrier family 40 member 1 | Iron ion transmembrane transporter |
FBP1 | Fibropellin-1 | NOTCH binding | |
9 189 features | U520 | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase | ATP/RNA-binding |
| HSP71 | Heat shock 70 protein 1 | Protein folding chaperone |
UBIQP | Polyubiquitin | Different functions depending on what protein it is attached to | |
CP1A1 | Cytochrome p450 1A1 | Heme-binding |
