Table 3 Predictive factors for tumors with high tumor-infiltrating lymphocyte levels.

From: Relationship of the standard uptake value of 18F-FDG-PET-CT with tumor-infiltrating lymphocytes in breast tumors measuring ≥ 1 cm

 

Univariable analysis

Multivariable analysis

ORs (95% CIs)

p value

ORs (95% CIs)

p value

Age

1.029 (0.997–1.061)

0.074

1.017 (0.982–1.054)

0.337

Histology

 IDC

Ref

0.202

  

 ILC

0.209 (0.027–1.628)

0.135

  

 Others

0.335 (0.042–2.697)

0.304

  

T stage

 1

Ref

   

 2–3

1.540 (0.778–3.048)

0.216

  

N stage

 0

Ref

   

 1–3

0.824 (0.374–1.816)

0.631

  

Histologic grade

 I or II

Ref

   

 III

4.873 (2.323–10.223)

 < 0.001

1.508 (0.534–4.255)

0.438

Nuclear grade

 1 or 2

Ref

   

 3

4.375 (2.145–8.923)

 < 0.001

2.248 (1.000–5.053)

0.050

ER( +) (Ref: ( −))

0.234 (0.109–0.503)

 < 0.001

  

PR( +) (Ref: ( −))

0.258 (0.127–0.524)

 < 0.001

  

HER2( +) (Ref: ( −))

3.172 (1.496–6.722)

0.003

  

Subtypes

 Luminal/HER2( −)

Ref

 < 0.001

  

 HER2( +)

5.856 (2.472–13.873)

 < 0.001

3.166 (1.218–8.229)

0.018

 TNBC

5.916 (2.316–15.112)

 < 0.001

3.706 (1.329–10.340)

0.012

Ki-67 labeling index ≥ 14% (Ref: <14%)

3.922 (1.863–8.258)

 < 0.001

1.512 (0.604–3.785)

0.377

AR (%)

0.984 (0.972–9.995)

0.005

1.001 (0.983–1.020)

0.879

SUVmax

1.211 (1.092–1.344)

 < 0.001

1.140 (1.011–1.285)

0.032

  1. Bold font is used to also highlight statistically significant values.
  2. ANC absolute neutrophil count, ALC absolute lymphocyte count, ER estrogen receptor, HER-2 human epidermal growth factor receptor-2, IDC invasive ductal carcinoma, PR progesterone receptor, TNBC triple-negative breast cancer, OR odds ratio, CI confidence interval, AR androgen receptor, ILC invasive lobular carcinoma.
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