Table 4 Factors associated with nonresponsiveness to pre-ESRD care based on multiple logistic regression in the crude model, full model (with and without imputation), KFRE (Kidney Failure Risk Estimation), and RCRP (Renal Care Responsiveness Prediction).
N | Crude model | Full model (N = 3001) | Full model (MI) (N = 7110) | KFRE (N = 4080) | RCRP (N = 3360) | |
|---|---|---|---|---|---|---|
Odds ratio (95% CI) | Odds ratio (95% CI) | Odds ratio (95% CI) | Odds ratio (95% CI) | Odds ratio (95% CI) | ||
Demographic | ||||||
Age | 7110 | 1.000 (0.996, 1.003) | 1.001 (0.993, 1.008) | 0.997 (0.992, 1.003) | 0.999 (0.994, 1.005) | 0.994 (0.988, 1.000) |
Male | 7110 | 1.082 (0.977, 1.199) | 1.178 (0.966, 1.437) | 1.100 (0.963, 1.256) | 1.027 (0.893, 1.183) | 1.649 (1.382, 1.972) |
BMI | 6951 | 1.017 (1.005, 1.029) | 1.027 (1.006, 1.048) | 1.006 (0.993, 1.021) | ||
Smoking, former (Ref: Never) | 7110 | 0.951 (0.781, 1.151) | 0.601 (0.382, 0.932) | 0.771 (0.583, 1.020) | ||
Smoking, current (Ref: Never) | 1.036 (0.872, 1.227) | 0.908 (0.677, 1.212) | 0.975 (0.803, 1.184) | |||
Alcohol consumption, former (Ref: Never) | 7110 | 1.116 (0.889, 1.394) | 1.513 (0.940, 2.446) | 1.276 (0.927, 1.757) | ||
Alcohol consumption, current (Ref: Never) | 0.931 (0.700, 1.225) | 0.766 (0.449, 1.273) | 0.905 (0.668, 1.227) | |||
Education level (year), 9 ≤ ~ < 12 (Ref: < 9) | 7110 | 1.024 (0.900, 1.165) | 1.012 (0.819, 1.252) | 1.020 (0.887, 1.173) | ||
Education level (year), 12 ≤ ~ < 16 (Ref: < 9) | 1.076 (0.931, 1.242) | 1.102 (0.848, 1.434) | 1.101 (0.929, 1.303) | |||
Education level (year), 16 + (Ref: < 9) | 1.009 (0.845, 1.204) | 1.054 (0.757, 1.463) | 1.069 (0.871, 1.312) | |||
Diabetes | 7106 | 1.602 (1.445, 1.777) | 1.419 (1.183, 1.701) | 1.445 (1.258, 1.661) | 1.314 (1.109, 1.557) | |
Hypertension | 7106 | 1.378 (1.237, 1.536) | 0.981 (0.792, 1.216) | 1.086 (0.945, 1.248) | 1.213 (1.011, 1.457) | |
Cardiovascular disease | 7106 | 1.203 (1.085, 1.334) | 1.029 (0.840, 1.259) | 1.061 (0.924, 1.219) | ||
Medication | ||||||
NSAIDs | 6956 | 0.983 (0.875, 1.104) | 1.154 (0.962, 1.383) | 0.918 (0.809, 1.043) | 1.016 (0.851, 1.212) | |
Anti-platelet | 6956 | 1.212 (1.090, 1.348) | 0.961 (0.784, 1.178) | 1.003 (0.876, 1.147) | ||
Urate-lowering agents | 6956 | 0.991 (0.882, 1.112) | 0.929 (0.768, 1.123) | 1.059 (0.930, 1.206) | ||
ACEIs/ARBs | 6956 | 1.480 (1.333, 1.643) | 1.329 (1.092, 1.619) | 1.212 (1.061, 1.384) | ||
Trichlorethiazide | 6956 | 1.263 (1.140, 1.399) | 0.959 (0.792, 1.160) | 1.028 (0.904, 1.169) | ||
Pentoxifylline | 6956 | 1.201 (1.069, 1.348) | 1.072 (0.897, 1.279) | 1.103 (0.968, 1.257) | ||
Baseline biochemical parameters | ||||||
eGFR (mL/min/1.73 m2) | 7110 | 1.001 (0.998, 1.003) | 1.000 (0.994, 1.006) | 0.988 (0.984, 0.992) | 1.010 (1.006, 1.014) | |
Pooled urine PCR (per 100 mg/g cre) | 5669 | 1.013 (1.011, 1.015) | 1.013 (1.009, 1.016) | 1.007 (0.995, 1.018) | 1.014 (1.011, 1.017) | 1.016 (1.013, 1.020) |
Calcium (mg/dL)) | 5319 | 0.977 (0.892, 1.069) | 1.020 (0.876, 1.188) | 1.052 (0.930, 1.190) | 1.135 (1.001, 1.287) | 0.962 (0.826, 1.120) |
Phosphate (mg/dL) | 4935 | 0.808 (0.756, 0.862) | 0.861 (0.773, 0.959) | 0.919 (0.843, 1.001) | 0.766 (0.704, 0.833) | 0.966 (0.870, 1.070) |
Serum Albumin (g/dL) | 5857 | 0.713 (0.654, 0.776) | 0.901 (0.761, 1.068) | 0.793 (0.649, 0.970) | 0.885 (0.772, 1.015) | 1.074 (0.913, 1.264) |
Hemoglobin (g/dL) | 5477 | 1.011 (0.986, 1.036) | 0.937 (0.892, 0.983) | 0.944 (0.910, 0.980) | 0.852 (0.814, 0.892) | |
Serum creatinine (mg/dL) | 7110 | 0.744 (0.715, 0.772) | 0.485 (0.445, 0.527) | |||
Blood urea nitrogen (mg/dL) | 6613 | 0.986 (0.983, 0.988) | 0.971 (0.965, 0.977) | 0.969 (0.965, 0.974) | ||
Serum uric acid (mg/dL) | 6294 | 0.994 (0.968, 1.021) | 1.025 (0.982, 1.070) | 1.027 (0.997, 1.059) | ||
T-CHO (mg/dL) | 6018 | 1.001 (1.000, 1.002) | 0.999 (0.998, 1.001) | 1.000 (0.999, 1.002) | ||
