Figure 3

Histologic findings of adverse events in the phase 1 study. (a) Partial loss of the muscularis propria and surrounding inflammation with necrotic changes were exhibited at the ablation site of the esophagus treated with 2500 V (1190.5 V/cm). Hematoxylin and eosin (H&E), 20 × magnification. (b) Diffuse mucosal necrosis with extensive hemorrhaging in the submucosal layer were observed after ablation of the stomach at 2000 V (2000 V/cm). H&E, 40 × magnification. (c) The muscularis propria and submucosal layers showed complete destruction and submucosal hemorrhaging with congestion with ablation of the duodenum at 2000 V (952.4 V/cm). H&E, 20 × magnification. (d) normal esophagus. (e) normal stomach. (f) normal duodenum. H&E, 40 × magnification.