Correction to: Scientific Reports https://doi.org/10.1038/srep20320 published online 03 February 2016
This Article contains errors.
In Figure 3H, the figures for the control group (BDNF+/+ mice) were mistakenly selected from the candidate representative images for IBS-D FSN group (BDNF+/+ mice).
The correct Figure 3 and its accompanying legend appear below.
Alterations of visceral sensitivity and expressions of BDNF, GFAP and substance P in colon of BDNF+/+ and BDNF+/− mice in the presence or absence of IBS fecal supernatants (FSN) stimulation. (A) Intracolonic infusion of IBS-D FSN significantly increased electromyographic (EMG) activity of abdominal muscles in wild-type mice (*, IBS-D FSN vs. control). (B) TrkB/Fc significantly suppressed the effect of IBS-D FSN at 30, 45 and 60 mmHg (*, IBS-D FSN vs. control; #, IBS-D FSN vs. IBS-D FSN plus TrkB/Fc). (C) The overall response to the CRD after treatment by IBS-D FSN in BDNF+/− mice was significantly lower than that in BDNF+/+ mice. (*, IBS-D FSN vs. control FSN in BDNF+/− mice; #, IBS-D FSN in BDNF+/+ mice vs. in BDNF+/− mice; †control FSN in BDNF+/+ mice vs. in BDNF+/− mice). (D–F) Western blotting analysis of BDNF, GFAP and TrkB protein levels in colon of BDNF+/+ and BDNF+/− mice 4 h after intracolonic infusion with IBS-D FSN compared with control FSN or aprotinin-pretreated IBS-D FSN. (G) Overview of GFAP expression in the full-thickness colonic wall in BDNF+/+ mice 4 h after intracolonic infusion with IBS-D FSN compared with control FSN. Black arrow shows increased expression of GFAP in muscular layers. (H) Dual immunofluorescence staining of SP and GFAP in colon of BDNF+/+ and BDNF+/− mice 4 h after intracolonic infusion with IBS-D FSN compared with control FSN or aprotinin-pretreated IBS-D FSN. Co-immunostaining for colonic SP and GFAP was significantly increased in BDNF+/+ mice (I) but not in BDNF+/− mice (J) after 4-hour intracolonic incubation with IBS-D FSN. The results are displayed as the mean ± SD. (*P < 0.05 **P < 0.01, ***P < 0.001, ##P < 0.01, ###P < 0.001, †P < 0.05; AUC, area under curve; NS, not significant; target protein levels were normalized to GAPDH; n = 8 per group; scale bars: 50 μm). The gels were run under the same experimental conditions. Cropped gels/blots are presented. (Full-length gels/blots are shown in Suppl. Fig. S2 with indicated cropping lines.)
These changes do not affect the conclusions of the article.
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Wang, P., Du, C., Chen, FX. et al. Author Correction: BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit. Sci Rep 11, 19139 (2021). https://doi.org/10.1038/s41598-021-98826-8
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DOI: https://doi.org/10.1038/s41598-021-98826-8
