Figure 4 | Scientific Reports

Figure 4

From: Author Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia

Figure 4

Polyclonal hematopoiesis in the TN-ET patients harboring comparable serum levels of cytokines for megakaryopoiesis. (A) Typical profiles of capillary electrophoresis of HpaII-digested gDNA from granulocytes (n = 10) or MNCs (n = 5) and CD3-positive cells. Two HpaII-resistant peaks representing maternal and paternal alleles in polyclonal hematopoiesis. One of these alleles becomes HpaII-sensitive in granulocytes, representing clonal hematopoiesis (arrow). (B) A pie chart presenting the frequencies of clonal and polyclonal hematopoiesis judged by the HUMARA assay in TN-ET. Four of 15 patients who exhibited ambiguous patterns in the HUMARA assay (A) were excluded from the analysis. Comparison of TPO (C) and IL-6 (D) concentrations in the serum among the patients with TN-ET, patients with ET harboring driver mutations, and healthy controls.

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