Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-97106-9, published online 06 September 2021


The original version of this Article contained errors.


As a result of errors in translation of the results from Japanese into English during preparation of the manuscript, some of the values reported in the paper are off - either by one or two orders of magnitude. This is because of incorrect conversion of Japanese symbol which denotes 104 into 103. This affects RBC count in Table 1, and platelet count in Figure 1E, Table 1 and Supplementary Table 1. These errors are now corrected. Additionally, the Authors revised Figure 1C and WBC row in Table 1 to make reporting of the units consistent. In EPO and Fe lines in Table 1 unit was also added. Figure 4 was corrected to remove spurious arrows in panel 4A.


Original Figure 1 is reproduced below for the record.

Figure 1
figure 1

Comparison of clinical parameters between the TN-ET patients and mutated ET patients. (A) Frequencies of driver mutations in the ET patients in our cohort. (B) A diagram presenting the mutation profiles of the TN-ET patients. NC-JAK2/MPL: noncanonical JAK2 and MPL mutation. The WBC count (C), Hb value (D), platelet count (E), and LDH level (F) for the patients classified based on driver mutation status are shown. Gray highlight shows normal range. * < 0.05, ** < 0.01, *** < 0.001, ns: not significant.

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Original Figure 4 is reproduced below for the record.

Figure 4
figure 4

Polyclonal hematopoiesis in the TN-ET patients harboring comparable serum levels of cytokines for megakaryopoiesis. (A) Typical profiles of capillary electrophoresis of HpaII-digested gDNA from granulocytes (n = 10) or MNCs (n = 5) and CD3-positive cells. Two HpaII-resistant peaks representing maternal and paternal alleles in polyclonal hematopoiesis. One of these alleles becomes HpaII-sensitive in granulocytes, representing clonal hematopoiesis (arrow). (B) A pie chart presenting the frequencies of clonal and polyclonal hematopoiesis judged by the HUMARA assay in TN-ET. Four of 15 patients who exhibited ambiguous patterns in the HUMARA assay (A) were excluded from the analysis. Comparison of TPO (C) and IL-6 (D) concentrations in the serum among the patients with TN-ET, patients with ET harboring driver mutations, and healthy controls.

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Original Table 1 is reproduced below for the record.

Table 1 Clinical characteristics of the ET patients grouped by driver mutation status.
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Original Supplementary Table 1 is reproduced below as Table 2 for the record.

Table 2 Clinical, biological, and genetic characteristics of TN-ET patients.
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Finally, in the Results, under the subheading ‘Noncanonical JAK2 and MPL mutant exhibits wild-type-equivalent levels of STAT5 activation’,


“One such patient was found to harbor MPL S204F in the abovementioned screening of noncanonical JAK2 and MPL mutations.”


now reads


“One such patient was found to harbor MPL S204F.”


These errors do not affect the conclusions of the Article. The Article and the accompanying Supplementary Information file have been corrected.