Figure 1

Serum free hemoglobin level and volumes of white matter hyperintensities. ICV intracranial volume VWMH volume of total white matter hyperintensity, VPVWMH volume of periventricular white matter hyperintensity, VDWMH volume of deep white matter hyperintensity. Restricted cubic spline analyses for the association of serum free hemoglobin level with volumes of white matter hyperintensities. Volumes of total (A), periventricular (B), and deep (C) white matter hyperintensities and serum free hemoglobin level in male older adults, and volumes of total (D), periventricular (E), and deep (F) white matter hyperintensities and serum free hemoglobin level in female older adults. All the volumes were normalized to individuals’ intracranial volumes and log-transformed.